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  • Scientific publications

2023

Transiently heritable fates and quorum sensing drive early IFN-I response dynamics

Single-cell analysis reveals TLR-induced macrophage heterogeneity and quorum sensing dictate population wide anti-inflammatory feedback in response to LPS

2022

Understanding natural killer cell biology from a single cell perspective

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Polymersomes as a potential platform for cancer immunotherapy

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A micropillar array-based microfluidic chip for label-free separation of circulating tumor cells: the best micropillar geometry?

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Artificial antigen-presenting cell topology dictates T cell activation

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A universal microfluidic approach for integrated analysis of temporal homocellular and heterocellular signaling and migration dynamics

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Microfluidic chip for precise trapping of single cells and temporal analysis of signaling dynamics

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Hydrogels for single-cell microgel production: recent advances and applications

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Guidelines for mouse and human DC generation

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Revising immune cell coordination: origins and importance of single-cell variation

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A microfluidic approach for probing heterogeneity in cytotoxic T-cells by cell pairing in hydrogel droplets

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Single cell profiling reveals functional heterogeneity and serial killing in human peripheral and ex vivo-generated CD34+ progenitor-derived Natural Killer cells

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2021

Phenotypical diversification of early IFNα-producing human plasmacytoid dendritic cells using droplet-based microfluidics

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Decoding the dynamics of multilayered stochastic antiviral IFN-I responses

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An automated real-time microfluidic platform to probe single NK cell heterogeneity and cytotoxicity on-chip

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Probing probing single-cell macrophage polarization and heterogeneity using thermo-reversible hydrogels in droplet-based microfluidics

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Robust antigen-specific T cell activation within injectable 3D synthetic nanovaccine depots

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2020

Programmable bivalent peptide–DNA locks for pH-based control of antibody activity

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2019

A pipette-tip based method for seeding cells to droplet microfluidic platforms

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Development of morphologically discrete PEG-PDLLA nanotubes for precision nanomedicine

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2018

Synthetic immune niches for cancer immunotherapy

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Customizing poly(lactic-co-glycolic acid) particles for biomedical applications

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Cytokine-functionalized synthetic dendritic cells for T cell targeted immunotherapies

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Single-cell analysis reveals that stochasticity and paracrine signaling control interferon-alpha production by plasmacytoid dendritic cells

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Integrating immunology and microfluidics for single immune cell analysis

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Injectable biomimetic hydrogels as tools for efficient T cell expansion and delivery

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2017

Controlling T-cell activation with synthetic dendritic cells using the multivalency effect

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A membrane-anchored aptamer sensor for probing of IFNγ secretion by single cells

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Affinity-based purification of polyisocyanopeptide bioconjugates

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2016

Circulating apoptotic microparticles in systemic lupus erythematosus patients drive the activation of dendritic cell subsets and prime neutrophils for NETosis

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Effective clinical responses in metastatic melanoma patients after vaccination with primary myeloid dendritic cells

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A comparative study of the T cell stimulatory and polarizing capacity of human primary blood dendritic cell subsets

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Long-lasting multifunctional CD8+ T cell responses in end-stage melanoma patients can be induced by dendritic cell vaccination

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Co-delivery of PLGA encapsulated invariant NKT cell agonist with antigenic protein induce strong T cell-mediated anti-tumor immune responses

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Preclinical exploration of combining plasmacytoid and myeloid dendritic cell vaccination with BRAF inhibition

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Dendritic cells as vaccines: key regulators of tolerance and immunity

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Proteomics of human dendritic cell subsets reveals subset-specific surface markers and differential inflammasome function

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CLEC12A-mediated antigen uptake and cross-presentation by human dendritic cell subsets efficiently boost tumor-reactive T cell responses

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2015

Polymer-based synthetic dendritic cells for tailoring robust and multifunctional T cell responses

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PLGA-encapsulated perfluorocarbon nanoparticles for simultaneous visualization of distinct cell populations by 19F MRI

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Selective expression of the MAPK phosphatase Dusp9/MKP-4 in mouse plasmacytoid dendritic cells and regulation of IFN-β production

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Protamine-stabilized RNA as an ex-vivo stimulant of primary human dendritic cell subsets

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2014

Tumoricidal activity of human dendritic cells

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Crosstalk between dendritic cell subsets and implications for dendritic cell-based anticancer immunotherapy

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An electro-coalescence chip for effective emulsion breaking in droplet microfluidics

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Towards efficient cancer immunotherapy: advances in developing artificial antigen-presenting cells

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One drop at a time: toward droplet microfluidics as a versatile tool for single-cell analysis

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2013

Natural human plasmacytoid dendritic cells induce antigen-specific T-cell responses in melanoma patients

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Human plasmacytoid dendritic cells efficiently cross-present exogenous Ags to CD8+ T-cells despite lower Ag uptake than myeloid dendritic cell subsets

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CD56 marks human dendritic cell subsets with cytotoxic potential

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Naturally circulating dendritic cells to vaccinate cancer patients

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Antigen cross-presentation by dendritic cell subsets: one general or all sergeants?

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Targeting uptake receptors on human plasmacytoid dendritic cells triggers antigen cross-presentation and robust type I IFN secretion

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Probing cellular heterogeneity in cytokine-secreting immune cells using droplet-based microfluidics

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2012

The chemotherapeutic drug oxaliplatin differentially affects blood DC function dependent on environmental cues

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The C type lectin CLEC9A mediates antigen uptake and (cross-)presentation by human blood BDCA3+ myeloid dendritic cells

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Harnessing human plasmacytoid dendritic cells as professional APCs

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Targeted delivery of CpG ODN to CD32 on human and monkey plasmacytoid dendritic cells augments IFNα secretion

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Deciphering the message broadcast by tumor infiltrating dendritic cells

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Human plasmacytoid dendritic cells are equipped with antigen-presenting and tumoricidal capacities

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Potential applications for plasmacytoid dendritic cells in cancer immunotherapy

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Interleukin-15-induced CD56+ myeloid dendritic cells combine potent tumor antigen presentation with direct tumoricidal potential

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2011

IL-4 and IL-13 alter plasmacytoid dendritic cell responsiveness to CpG DNA and Herpes simplex virus-1

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DEC-205 mediates antigen uptake and presentation by both resting and activated human plasmacytoid dendritic cells

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Prophylactic vaccines mimic synthetic CpG oligonucleotides in their ability to modulate immune responses

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2010

Human plasmacytoid dendritic cells phagocytose, process, and present exogenous particulate antigen

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Toll-like receptor expression and function in human dendritic cell subsets: implications for dendritic cell-based anti-cancer immunotherapy

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Cross-talk between human dendritic cell subsets influences expression of RNA sensors and inhibits picornavirus infection

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